US 2017/0284924 A1 · SYSTEM AND METHOD FOR DEFORMING PARTICLES

Abstract

Embodiments of a system and method for deforming a can include a substrate including an inlet module and an outlet module; a fluidic pathway coupled to the inlet module and the outlet module, and including a sample branch operable to transmit the sample fluid; one or more sheath fluid branches flanking the sample branch and operable to transmit sheath having a sheath fluid viscosity higher than a sample fluid viscosity of the sample fluid; a delivery region initiating at a junction between the sample branch and the one or more sheath fluid branches, and operable to transmit a co-flow comprising the sample fluid and the sheath fluid; and a deformation region located downstream of the delivery region and operable to deform the one or more particles of the sample fluid based upon a reduced velocity of the sheath fluid with respect to the sample fluid in the co-flow.

Claims22

Dependent claims

A system for deforming a particle, the system comprising:

a substrate defining an inlet module and an outlet module;
a fluidic pathway coupled to the inlet module and the outlet module, the fluidic pathway comprising:
a sample fluid branch coupled to a sample fluid inlet and operable to transmit a sample fluid comprising the particle;
a first sheath fluid branch coupled to a sheath fluid inlet, the first sheath branch operable to transmit sheath fluid possessing a sheath fluid viscosity different from a sample fluid viscosity of the sample fluid;
a delivery region initiating at a junction between the sample fluid branch and the first sheath fluid branch, the delivery region operable to receive the sample fluid and the sheath fluid, and to transmit a co-flow comprising the sample fluid and the sheath fluid;
and
a deformation region positioned downstream of the delivery region and operable to deform the particle based upon a change in velocity of the sheath fluid with respect to the sample fluid in the co-flow.

4 more elements

A method for characterizing deformation of a first particle in a sample fluid, the method comprising:

receiving the sample fluid at a delivery region of a fluidic pathway;
receiving a sheath fluid at the delivery region of the fluidic pathway, wherein the sheath fluid pinches the sample fluid to generate a first co-flow comprising the sheath fluid and the sample fluid;
transmitting the first co-flow from the delivery region to a deformation region downstream of the delivery region in the fluidic pathway;
deforming the first particle at the deformation region based upon a change in velocity of the sheath fluid with respect to the sample fluid in the first co-flow;
capturing an optical dataset of the first particle traveling through the deformation region;
and
transforming the optical dataset into a morphology dataset describing the deformation of the first particle at the deformation region.

4 more elements

Dependencies are inferred from the claim text.

System and method for deforming particles

Life of this patent

System and method for deforming particles

Life of this patent

Abstract

Claims22