Methods for lung cancer detection
AssigneesFondazione Istituto Firc Di Oncologia Molecolare, Universita' Degli Studi Di Milano, Ieo - Istituto Europeo Di Oncologia S.R.L.
InventorsPier Paolo Di FIORE, Fabrizio BIANCHI, Francesco NICASSIO, Matteo Jacopo Luca Nicolo MARZI, Francesca MONTANI
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Abstract
The disclosure describes a method for diagnosing lung cancer in a subject by detecting in a biological sample obtained from that patient a miRNA signature, the presence of which provides an earlier indication of cancer than alternative art-recognized methods, including, but not limited to, low-dose computed tomography (LDCT).
Claims42
A method of diagnosing lung cancer in a subject in need thereof comprising
- (a) detecting in a biological sample from the subject a decrease in the abundance of each of hsa-mir-92a-3p, hsa-mir-30b-5p, hsa-mir-191-5p, hsa-mir-484, hsa-mir-328-3p, hsa-mir-30c-5p, hsa-mir-374a-5p, hsa-mir-7d-5p, and hsa-mir-331-3p compared to a control abundance value corresponding to each of hsa-mir-92a-3p, hsa-mir-30b-5p, hsa-mir-191-5p, hsa-mir-484, has-mir-328-3p, hsa-mir-30c-5p, hsa-mir-374a-5p, hsa-mir-7d-5p, and hsa-mir-331-3p from a control sample;
- (b) detecting in the biological sample an increase in the abundance of each of hsa-mir-29a-3p, hsa-mir-148a-3p, hsa-mir-223-3p, and hsa-mir-140-5p compared to a control abundance value corresponding to each of hsa-mir-29a-3p, hsa-mir-148a-3p, hsa-mir-223-3p, and hsa-mir-140-5p from a control sample;
- and
- (c) diagnosing the subject with lung cancer, when a decreased abundance in each of the miRNA in (a) is detected and an increased abundance of each of the miRNA in (b) is detected.
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Dependencies are inferred from the claim text.