Methods and therapeutics relating to mrna biomarkers for clinical prognosis of cancer
OwnerTimothy J. Robinson, Mark W. Dewhirstinventors
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Abstract
This disclosure provides methods and compositions of matter relating to the monitoring of relative concentrations of pairs of isoforms of mRNA or downstream expression products thereof. The methods can include measuring a relative expression level of a pair of mRNA isoforms or downstream expression products thereof and comparing the relative expression level to relative historical or cohort expression levels of the same pair of mRNA isoforms. The result of the comparison can lead to a more accurate prognosis for the subject.
Claims21
A method of providing a prognosis to a subject suffering from an adenocarcinoma, the method comprising:
- a) obtaining a biological sample from the subject;
- b) measuring a relative expression level of one or more pairs of mRNA isoforms or downstream expression products thereof within the biological sample;
- and
- c) comparing the relative expression level to relative historical or contemporary cohort expression levels of the one or more pairs of mRNA isoforms or downstream expression products thereof, the relative historical or contemporary cohort expression levels retrieved from a historical or contemporary data set for historical or contemporary patients suffering from the adenocarcinoma.
19-21. (canceled)
A composition of matter comprising an artificially synthesized polymerase chain reaction primer selected from the group consisting of SEQ ID NO:
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A composition of matter comprising an artificially synthesized probe selected from the group consisting of SEQ ID NO:
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Dependencies are inferred from the claim text.