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AssigneeAcademia Sinica
InventorsChi-Huey WONG, Chung-Yi WU, Sarah K.C. CHEUNG, Po-Kai CHUANG, Tsui-Ling HSU
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The present disclosure relates to methods and compositions which can modulate the globoseries glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globoseries glycosphingolipid SSEA-3/SSEA-4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globoseries synthetic pathway. Additionally, the present disclosure is also directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA-3/SSEA-4/GLOBO H associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globoseries glycosphingolipid synthesis. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions. Furthermore, the instant disclosure also relates to cancer stem cell biomarkers for diagnostic and therapeutic uses.
A method for treating cancer in a subject in need thereof comprising:
A method for inducing apoptosis by down-regulating B3GalT5 activity in a host cell, comprising the steps of:
A method for detecting cancer and/or identifying subjects having increased risk of developing cancer, comprising the steps of:
A method of screening a candidate therapeutic agent for effectiveness against a cancer stem cell expressing a tumor-associated carbohydrate antigen, said method comprising:
A method for identifying a cancer comprising:
A method for identifying a population of cancer stem cells, the method comprising
Dependencies are inferred from the claim text.