Biomarker rnf6 for colorectal cancer
AssigneeThe Chinese University of Hong Kong
InventorsJUN YU, Joseph Jao Yiu Sung
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Abstract
The present invention provides a method for diagnosing of colorectal cancer in a subject and a method for determining risk of recurrence of colorectal cancer among colorectal cancer patients by detecting overexpression of the RNF6 gene, which in some cases is due to a higher than normal copy number of the genomic sequence of this gene. A kit and device useful for such methods are also provided. In addition, the present invention provides a method for treating colon cancer by suppressing RNF6 gene expression or activity.
Claims23
A method for assessing risk for colon cancer in a subject, comprising the steps of:
- (a) measuring RNF6 level in a sample taken from the subject,
- (b) comparing the RNF6 level obtained in step (a) with a standard control, and
- (c) determining the subject, who has an increased RNF6 level compared with the standard control, as having an increased risk for colon cancer.
-11. (canceled)
A method for assessing likelihood of recurrence of colon cancer in a colon cancer patient, comprising the steps of:
- (a) measuring RNF6 level in a colon cancer sample taken from the colon cancer patient,
- (b) comparing the RNF6 level obtained in step (a) with RNF6 level from another colon cancer sample of the same type obtained from a second colon cancer patient and measured by step (a), and
- (c) determining the patient, who has a higher RNF6 level compared with the RNF6 level determined in the other colon cancer sample of the same type obtained from a second colon cancer patient and measured by step (a), as having an increased risk for recurrence of colon cancer compared with the second colon cancer patient.
A kit for detecting colon cancer in a subject, comprising (1) a standard control that provides an average amount of RNF6 protein or RNF6 mRNA or an average copy number of RNF6 genomic sequence;
- and (2) an agent that specifically and quantitatively identifies RNF6 protein, RNF6 mRNA, or RNF6 genomic sequence.
24-29. (canceled)
A method for inhibiting growth of a colon cancer cell, comprising contacting the colon cancer cell with an effective amount of a neutralizing antibody against RNF6 protein or a nucleic acid encoding a polynucleotide sequence that is complementary to at least a segment of RNF6 mRNA and suppresses RNF6 mRNA expression.
-34. (canceled)
Dependencies are inferred from the claim text.