BIOENZYMATIC SYNTHESIS OF THC-v, CBV AND CBN AND THEIR USE AS THERAPEUTIC AGENTS
AssigneeFull Spectrum Laboratories Limited
InventorsMalcolm J. Kavarana, Richard C. Peet
Life of this patent
Estimating the term…
Abstract
The present invention provides methods for producing cannabinoids. More specifically, the invention is directed to the bio-enzymatic synthesis of THC-v, CBV and CBN by contacting a compound according to Formula I with a cannabinoid synthase enzyme. Also described is a system for producing these pharmaceutically important cannabinoids and the use of such cannabinoids as therapeutic agents.
Claims25
A method for producing a Formula II compound, comprising the steps of:
- contacting a compound according to Formula I:
- with a cannabinoid synthase in the presence of a solvent to produce a compound according to Formula II:
- wherein:
- R is —H, COOH, or —(CH2)nCOOH;
- R1 is selected from the group consisting of methyl, ethyl, propyl, butyl, pentyl, hexyl, and heptyl;
- and
- n is 1, 2, 3, 4, 5, or 6.
A method for producing a Formula III compound, comprising the steps of:
- (i) contacting a compound according to Formula I:
- with a cannabinoid synthase in the presence of a solvent to produce a compound according to Formula II:
- and
- (ii) oxidizing the Formula II compound to produce a compound according to Formula III:
- wherein:
- R is —H, COOH, or —(CH2)nCOOH;
- R1 is selected from the group consisting of methyl, ethyl, propyl, butyl, pentyl, hexyl, and heptyl;
- and
- n is 1, 2, 3, 4, 5, or 6.
A system for producing a Formula V compound, comprising:
- (i) a bioreactor containing a reactant according to Formula IV, a solvent, and a cannabinoid synthase;
- (ii) a control mechanism configured to control at least one condition of the bioreactor, wherein the compound according to Formula IV interacts with the cannabinoid synthase to produce a compound according to Formula V;
- wherein
- R4 is —H, COOH, or —(CH2)nCOOH;
- R5 is selected from the group consisting of methyl, ethyl, propyl, butyl, pentyl, hexyl, and heptyl;
- and
- n is 1, 2, 3, 4, 5, or 6.
A system for producing a Formula VI compound, comprising:
- a bioreactor containing a reactant according to Formula IV, a solvent, and a cannabinoid synthase;
- a control mechanism configured to control at least one condition of the bioreactor, wherein the compound according to Formula IV interacts with the cannabinoid synthase to produce a compound according to Formula V;
- and
- oxidizing the Formula V compound to produce a compound according to Formula VI
- wherein
- R4 is —H, COOH, or —(CH2)nCOOH;
- R5 is selected from the group consisting of methyl, ethyl, propyl, butyl, pentyl, hexyl, and heptyl;
- and
- n is 1, 2, 3, 4, 5, or 6.
Dependencies are inferred from the claim text.