Biocatalysts and methods for synthesizing derivatives of tryptamine and tryptamine analogs
AssigneeCodexis, Inc.
InventorsJovana Nazor, Derek J. Smith, Michael A. Crowe, Shiwei Song, Steven J. Collier
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Abstract
The present disclosure provides engineered transaminase polypeptides for the production of amines, polynucleotides encoding the engineered transaminases, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases to prepare compounds useful in the production of active pharmaceutical agents.
Claims23
An engineered polypeptide having transaminase activity, comprising an amino acid sequence having at least 80% identity to SEQ ID NO:2 and one or more residue differences as compared to SEQ ID NO:2 at residue positions selected from:
- X113, X383, X420, and X424.
Dependencies are inferred from the claim text.