Artificial peritoneal tissue and method for producing same
AssigneesHirosaki University, Osaka University
InventorsHiroshi SHIMODA, Yoshiya ASANO, Mitsuru AKASHI, Michiya MATSUSAKI
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Abstract
The present disclosure relates to: an artificial peritoneal tissue comprising a cellular tissue and a mesothelial cell layer that covers the surface of the cellular tissue, wherein the cellular tissue comprises a fibroblast, an extracellular matrix, and a vascular endothelial cell and/or a lymphatic endothelial cell each capable of forming a lumen; and a method for producing the artificial peritoneal tissue.
Claims10
An artificial peritoneal tissue comprising:
- a cellular tissue;
- and
- a mesothelial cell layer that covers a surface of the cellular tissue,
- the cellular tissue comprising a fibroblast, an extracellular matrix, and at least one of a vascular endothelial cell and a lymphatic endothelial cell forming a lumen,
- wherein
- the fibroblast is derived from a fibroblast coated with an extracellular matrix, and
- at least one of the vascular endothelial cell and the lymphatic endothelial cell is derived from at least one of a vascular endothelial cell coated with an extracellular matrix and a lymphatic endothelial cell coated with an extracellular matrix.
A method for producing an artificial peritoneal tissue comprising a cellular tissue and a mesothelial cell layer that covers a surface of the cellular tissue, the cellular tissue comprising a fibroblast, an extracellular matrix, and at least one of a vascular endothelial cell and a lymphatic endothelial cell forming a lumen, the method comprising:
- culturing at least one of a vascular endothelial cell and a lymphatic endothelial cell, a fibroblast, and an extracellular matrix to form the cellular tissue;
- and
- placing a mesothelial cell on the cellular tissue,
- wherein forming the cellular tissue comprises:
- placing a fibroblast coated with the extracellular matrix;
- and
- placing at least one of a vascular endothelial cell coated with the extracellular matrix and a lymphatic endothelial cell coated with the extracellular matrix.
(canceled)
Dependencies are inferred from the claim text.