Modified Cells Evoking Reduced Immunogenic Responses
AssigneeZhejiang University
InventorsLei Xiao, Haide Chen, Chun Cui, Yang Li, Di Cui
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Abstract
The present disclosure describes composition, methods, and systems associated with a genetically modified stem cell. The modified stem cell includes a reduced amount of Major Histocompatibility Complex II (MHC II) as compared to a corresponding wild-type cell. Further, the modified cell has decreased immunogenicity as compared to the corresponding wild-type cell.
Claims18
A modified cell comprising a disruption of MHC class II transactivator (CIITA) gene, wherein the modified cell is a modified stem cell or a cell derived from the modified stem cell.
A method of reducing T cell responses to presentation of a cell, the method comprising Introducing a disruption of MHC class II transactivator (CIITA) gene of the cell to obtain a modified cell, wherein the cell is a stem cell or a cell derived from the stem cell, the disruption of CIITA of the cell produces a reduced T cell responses to the presentation of the modified cell as compared to a wild-type cell.
Dependencies are inferred from the claim text.