Modified j-chain
AssigneeIGM Biosciences, Inc.
InventorsBruce KEYT, Leonard George PRESTA, Fen ZHANG, Ramesh BALIGA
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Abstract
The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies comprising the same, and their uses.
Claims40
An IgM, IgA, IgG/IgM, or IgG/IgA antibody comprising a modified J-chain, wherein the modified J-chain comprises an extraneous binding moiety introduced into a native sequence J-chain.
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A composition comprising an IgM, IgA, IgG/IgM, or IgG/IgA antibody comprising a modified J-chain, wherein the modified J-chain comprises an extraneous binding moiety introduced into a native sequence J-chain.
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A modified J-chain comprising an extraneous binding moiety introduced into a native sequence J-chain.
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Dependencies are inferred from the claim text.