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US 2017/0283502 A1Published application
Compositions and methods for treating and preventing inflammation
AssigneeRsem, Limited Partnership
InventorsPrzemyslaw Sapieha, Normand Beaulieu
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Abstract
The present invention provides novel compounds compositions and methods for (i) treating or preventing inflammation; and (ii) preventing or reducing hyperactivation of innate immune response, by inhibiting NRP1-dependent cell-signaling. Also provided are compounds, composition, and methods of specifically inhibiting SEMA3A-mediated cell signaling.
Claims22
1-69. (canceled)
A method of treating or preventing (i) neurological damage induced by a stroke or cerebral ischemia;
- (ii) septic shock;
- or (iii) inflammation, comprising inhibiting NRP1-dependent cell-signaling in a subject.
A NRP1 trap comprising a NRP1 polypeptide consisting of:
- (i) SEQ ID NO:
- 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, or 113 lacking a signal peptide or a functional variant thereof;
- or (ii) SEQ ID NO:
- 1, 3, 5, 7, 9, 12, 13, 15, 17, 19, 21, 23, 31, 33, 35, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 83 or a functional variant thereof.
1 more element
A NRP1 trap comprising a NRP1 polypeptide consisting of:
- SEQ ID NO:
- 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, or 113 or a functional variant thereof and further comprising a protein purification domain.
Dependencies are inferred from the claim text.