US 2017/0283485 A1 · ANTIBODY CAPABLE OF BINDING TO INFLUENZA VIRUS

Abstract

The present invention provides a novel antibody capable of binding influenza virus. The antibody directed to the present invention consists of an amino acid sequence, wherein said amino acid sequence consists of, in an N- to C-direction, the following structural domains: N-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4-C FR denotes a framework region amino acid sequence and CDR denotes a complementary determining region amino acid sequence; the CDR1 consists of an amino acid sequence represented by SYYMS (SEQ ID NO: 01) the CDR2 consists of an amino acid sequence represented by TINTGGGSTYYADSVKG (SEQ ID NO: 02); the CDR3 consists of an amino acid sequence represented by DGPYGGYDY (SEQ ID NO: 03); and the antibody is capable of binding to H12N1 influenza virus. Desirably, the FR1-FR4 consist of amino acid sequences represented by EVQLVESGGGLVQPGGSLRVSCAASGFTFS (SEQ ID NO: 04), WVRQAPGKGLEWVS (SEQ ID NO: 05), RFTISRDNAKNTLYLQMDSLKSEDTAVYYCAK (SEQ ID NO: 06), and WGQGTQVTVSP (SEQ ID NO: 07), respectively.

Claims2

Dependent claims

An antibody that consists of an amino acid sequence, wherein said amino acid sequence consists of, in an N- to C-direction, the following structural domains:

N-FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4-C
wherein
FR denotes a framework region amino acid sequence and CDR denotes a complementary determining region amino acid sequence;
the CDR1 consists of an amino acid sequence represented by SYYMS (SEQ ID NO:
01)
the CDR2 consists of an amino acid sequence represented by TINTGGGSTYYADSVKG (SEQ ID NO:
02);
the CDR3 consists of an amino acid sequence represented by DGPYGGYDY (SEQ ID NO:
03);
and
the antibody is capable of binding to H12N1 influenza virus.

8 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/388,196Filed 22 Dec 2016

Priority

1 Apr 2016

Published

5 Oct 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification5 codes

C07K 16/108
RNA viruses: orthomyxoviridae , e.g. influenza virus
C07K 2317/22
Characterized by taxonomic origin: from camelids, e.g. camel, llama or dromedary
C07K 2317/569
Variable region, i.e. VH and/or VL: single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
C07K 2317/92
Characterized by kinetic aspects or by stability of the immunoglobulin: affinity , association rate , dissociation rate or EC50 value

Antibody capable of binding to influenza virus

Life of this patent

Antibody capable of binding to influenza virus

Life of this patent

Abstract

Claims2