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US 2017/0283476 A1Published application
Myc nucleic acids and uses thereof
AssigneeAvidity Biosciences, Inc.
InventorsHanhua HUANG, Rob BURKE
Life of this patent
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Abstract
Disclosed herein are molecules and pharmaceutical compositions that mediate RNA interference against MYC. Also described herein include methods for treating a disease or disorder that comprises a molecule or a pharmaceutical composition that mediate RNA interference against MYC.
Claims28
A polynucleic acid molecule that mediates RNA interference against MYC, wherein the polynucleic acid molecule comprises at least 80% sequence identity to a sequence selected from SEQ ID NOs:
- 1-12, wherein the polynucleic acid molecule hybridizes to a MYC target sequence with less than 4 mismatched bases, wherein the polynucleic acid molecule comprises at least one 2′ modified nucleotide, at least one modified internucleotide linkage, or at least one inverted abasic moiety, and wherein the polynucleic acid molecule is from about 10 to about 50 nucleotides in length.
Dependencies are inferred from the claim text.