Cancer vaccine compositions and methods of use thereof
AssigneeUniversity of Washington
InventorsMary L. DISIS, Elizabeth BROUSSARD
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Abstract
The present application describes compositions that include an epitope of a peptide that elicits an immune response in a subject following administration. The compositions described herein include nucleic acids. The present application also describes compositions that include peptides. Also described herein are methods that include administering a composition comprising an epitope of a peptide to a subject in need thereof.
Claims27
1-82. (canceled)
A composition comprising an isolated and purified plasmid comprising a nucleotide sequence encoding a polypeptide, wherein the polypeptide comprises a plurality of sequences each comprising at least 90% sequence identity to an amino acid sequence selected from SEQ ID NOs:
- 1-22 and 27-45.
A composition comprising:
- a) a first isolated and purified plasmid comprising a first nucleotide sequence encoding a first polypeptide, wherein the first polypeptide comprises at least one sequence comprising at least 90% sequence identity to an amino acid sequence selected from SEQ ID NOs:
- 1-45, and
- b) a second isolated and purified plasmid comprising a second nucleotide sequence encoding a second polypeptide, wherein the second polypeptide comprises at least one sequence comprising at least 90% sequence identity to an amino acid sequence selected from SEQ ID NOs:
- 1-22 and 27-45;
- wherein the at least one sequence of the first polypeptide is different than the at least one sequence of the second polypeptide.
A method of treating a subject in need thereof, the method comprising administering to the subject in need thereof an isolated and purified plasmid comprising a nucleotide sequence encoding a polypeptide, wherein the polypeptide comprises a plurality of sequences each comprising at least 90% sequence identity to an amino acid sequence selected from SEQ ID NOs:
- 1-22 and 27-45.
Dependencies are inferred from the claim text.