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US 2017/0283471 A1Published application
Modified microbial toxin receptor for delivering agents into cells
AssigneePresident and Fellows of Harvard College
InventorsAdva Mechaly, Andrew J. McCluskey, R. John Collier
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Abstract
We described a novel system of targeted cell therapy with a protein toxin, such as anthrax toxin, that has been modified to re-direct it to a desired cell target instead of its natural cell target. The system can be used for, e.g., targeted killing of undesired cells in a population of cells, such as cancer or overly active immune system cells.
Claims20
An altered binary toxin system for delivery of an active molecule to a target cell comprising:
- a fusion protein comprising a receptor-ablated pore-forming AB toxin unit fused to a non-toxin-associated receptor-binding ligand specific for a target cell, and
- a complementary toxin unit capable of associating with the pore-forming toxin unit for delivery of a therapeutic protein to the cytosol of the target cell.
Dependencies are inferred from the claim text.