Peptides for diagnosis and treatment of cancer
AssigneeNational Taiwan University
InventorsCHIN-TARNG LIN, HAN-CHUNG WU
Life of this patent
Estimating the term…
Abstract
The present invention provides a method of peptide histochemical diagnosis to detect the peptide binding protein in the cancer tissue. This peptide binding specifically to tumor cells is linked to the dextran coated iron oxide nanoparticle. The peptide linked dextran coated iron oxide nanoparticle can be used to bind to the formalin-fixed and paraffin-embedded tumor surgical specimens, and the method of present invention can be used to evaluate the efficacy of peptide-targeted chemotherapy for treatment of cancer patients.
Claims15
A method of reducing the side effects of cancer chemotherapy by using peptides, comprising:
- administering to a subject suffering from a cancer an effective amount of a chemotherapeutic drug and peptides,
- wherein the peptides are at least two selected from the group consisting of amino acid sequences of SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:6.
A method of reducing the side effects of cancer chemotherapy by using peptide, comprising:
- administering to a subject suffering from a cancer an effective amount of
- a first set comprising a first chemotherapeutic drug and a first peptide, and
- a second set comprising a second chemotherapeutic drug and a second peptide,
- wherein each the first peptide and the second peptide is selected from the group consisting of amino acid sequences of SEQ ID NO:1, SEQ ID NO:2, and SEQ ID NO:6,
- wherein the second set is administered a period of time after the first set.
Dependencies are inferred from the claim text.