Programmable polypeptide and nucleic acid nanoparticles
AssigneeNorthwestern University
InventorsArmando Hernandez-Garcia, Samuel I. Stupp, Zaida Alvarez Pinto
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Abstract
Provided herein are polypeptides that self-assemble into nanoparticles upon binding to nucleic acids. The nanoparticles find use, for example in the delivery of the nucleic acids into cells.
Claims47
A polypeptide comprising an assembly domain and a nucleic-acid-binding domain (NABD), wherein upon binding of the NABD to a nucleic acid to form a polypeptide/nucleic acid complex, the assembly domain facilitates self-assembly of the polypeptide/nucleic acid complex into nanoparticles.
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Dependencies are inferred from the claim text.