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US 2017/0283466 A1Published application
Method for preparing multiple antigen glycopeptide carbohydrate conjugates
AssigneesInstitut Pasteur, Centre National De La Recherche Scientifique
InventorsSylvie Bay, Claude Leclerc, Richard Lo-Man
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Abstract
The present invention relates to a method for preparing carbohydrate T cell epitope conjugates of formula (I): M(T-B)n (I) wherein M, T, B and n ore as defined in claim 1.
Claims21
1-2. (canceled)
3-24. (canceled)
A method for preparing a carbohydrate T cell epitope conjugate of formula (I):
- wherein
- T is a peptide QYIKANSKFIGITEL (SEQ ID NO:
- 1);
- and
- R1 is:
- said method comprising the step of removing the Pr protecting groups from a compound of formula (II)
- wherein
- R1 is
- and
- Pr is a protecting group selected from the group consisting of:
- benzyl and acetyl.
8 more elements
A method for preparing a carbohydrate T cell epitope conjugate immobilized on a solid support, Z, via a β-Ala-residue, said T cell epitope conjugate having formula (III):
- wherein
- T is a peptide QYIKANSKFIGITEL (SEQ ID NO:
- 1);
- R1 is:
- and
- Pr is a protecting group, said protecting group selected from the group consisting of:
- benzyl and acetyl;
- R2 is Fmoc or H;
- said method comprising the step of coupling compounds of formula (IV):
- to a compound immobilized on a solid support via a β-Ala-residue, said compound immobilized on a solid support, Z, having formula (V):
- wherein
- T is a peptide QYIKANSKFIGITEL (SEQ ID NO:
- 1) and
- R1 is
11 more elements
A carbohydrate T cell epitope conjugate of the formula (VI):
- wherein
- T is a peptide QYIKANSKFIGITEL (SEQ ID NO:
- 1);
- R1 is:
- and
- wherein
- R2 is Fmoc or H.
4 more elements
Dependencies are inferred from the claim text.