US 2017/0283454 A1 · COMPOSITIONS COMPRISING CYCLIC PURINE DINUCLEOTIDES HAVING DEFINED STEREOCHEMISTRIES AND METHODS FOR THEIR PREPARATION AND USE

Abstract

It is an object of the present invention to provide novel and highly active cyclic-di-nucleotide (CDN) immune stimulators that activates DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides that induce STING-dependent TBK1 activation, wherein the cyclic purine dinuclotides present in the composition are substantially pure Rp,Rp or Rp,Sp stereoisomers, and particularly substantially pure Rp,Rp, or RpSp CDN thiophosphate diastereomers.

Claims1

Dependent claims

A composition comprising:

one or more cyclic purine dinucleotides or prodrugs or pharmaceutically acceptable salts thereof which induce STING-dependent TBK1 activation, wherein the cyclic purine dinuclotides present in the composition are substantially pure Rp,Rp or Rp,Sp diastereomers, or prodrugs or pharmaceutically acceptable salts thereof, wherein said cyclic purine dinucleotides are preferably thiophposphate cyclic purine dinucleotides.

Dependencies are inferred from the claim text.

Facts

Application

15/630,741Filed 22 Jun 2017

Priority

13 Dec 2012

Published

5 Oct 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification20 codes

C07H 21/02
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of…: with…
A61K 31/7084
Carbohydrates; Sugars; Derivatives thereof: compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide,…
A61K 39/0005
Medicinal preparations containing antigens or antibodies: vertebrate antigens
A61K 39/02
Medicinal preparations containing antigens or antibodies: bacterial antigens

Family

Application61/737,006Us provisional application · filed 13 Dec 2012

Application61/790,514Us provisional application · filed 15 Mar 2013

Application14/106,687Continuation · filed 13 Dec 2013

Application15/630,741Continuation

US 10,414,789 B2Related patent

US 2014/0205653 A1Published application

US 9,695,212 B2Related patent

US 2017/0283454 A1This patent

From the US filing history. Foreign family members aren’t listed.

Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use

Life of this patent

Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use

Life of this patent

Abstract

Claims1