N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as a2a agonists
AssigneeLewis and Clark Pharmaceuticals, Inc.
InventorsRobert D. Thompson, Anthony Beauglehole, Guoquan Wang
Life of this patent
Estimating the term…
Abstract
The present invention provides N-alkyl 2-(disubstituted)alkynyladenosine-5′-uronamides and derivatives thereof and pharmaceutical compositions containing the same that are selective agonists of A2A adenosine receptors (ARs). These compounds and compositions are useful as pharmaceutical agents.
Claims42
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A compound or a stereoisomer or pharmaceutically acceptable salt thereof, wherein the compound is a compound selected from Tables 1 and 2 as follows:
- TABLE 1
- Ex #
- Structure
- 1
- 6
- 8
- 9
- 10
- 13
- 15
- 19
- 20
- 21
- 29
- 30
- 31
- TABLE 2
- Ex. #
- Structure
- 1
- 2
- 4
- 5
- 6
- 10
- 11
- 27
- 29
- 32
Dependencies are inferred from the claim text.