SOLUBLE C5aR ANTAGONISTS

A compound of Formula (I)

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is selected from the group consisting of H, —O—CH2—O—P(O)ORaORb, —O—C(O)—C1-6 alkylene-L2-X1, O—P(O)ORaORb, and —O—C(O)-A1-(C1-3 alkylene)n-C4-7 heterocyclyl wherein the C4-7 heterocyclyl is optionally substituted with 1 to 6 Rc groups;
• A1 is selected from the group consisting of C6-10 aryl, C3-10 cycloalkyl, C5-10 heteroaryl and C5-10 heterocyclyl, each of which is optionally substituted with 1 to 5 Rx which can be the same or different;
• n=0 or 1;
• L2 is independently selected from the group consisting of a bond, —O—C(O)—C1-6 alkylene-, and —NRd—C(O)—C1-6 alkylene-;
• X1 is independently selected from the group consisting of —NReRf, —P(O)ORaORb, —O—P(O)ORaORb, and —CO2H;
• R2 is selected from the group consisting of H, -L3-C1-6 alkylene-L4-X2, -L3-(C1-6 alkylene)m-A2-X2, —P(O)ORaOC(O)—C1-6 alkyl, —P(O)ORaNRgRh and —P(O)ORaORb,
• L3 is independently selected from the group consisting of —C(O)—O—, and —C(O)—;
• L4 is independently selected from the group consisting of a bond, —O—C(O)—C2-6 alkenylene-, —O—C(O)—C1-6 alkylene-, and —NRd—C(O)—C1-6 alkylene- wherein the C1-6 alkylene in —NRd—C(O)—C1-6 alkylene- and —O—C(O)—C1-6 alkylene- is optionally substituted with NReRf;
• X2 is independently selected from the group consisting of —NRkRl, —P(O)ORaORb, —O—P(O)ORaORb, and —CO2H;
• m=0 or 1;
• A2 is selected from the group consisting of C6-10 aryl, C3-10 cycloalkyl, C5-10 heteroaryl and C5-10 heterocyclyl, each of which is optionally substituted with 1 to 5 Rx which can be the same or different;
• R3 is H or -L5-P(O)ORaORb wherein L5 is independently selected from the group consisting of a bond and —CH2—O—;
• each Rx is independently selected from the group consisting of halogen, C1-6alkyl, C1-6 haloalkyl, C1-6heteroalkyl, CN, NRyRz, SRy and ORy;
• each Rc is independently selected from the group consisting of halogen, C1-6alkyl, C1-6 haloalkyl, C1-6heteroalkyl, CN, NRyRz, SRy and ORy;
• each Ra, Rb, Rd, Re, Rf, Rg, Rk, Rl, Ry and Rz is independently selected from the group consisting of H and C1-6 alkyl;
• each Rh is independently selected from the group consisting of H and C1-6 alkyl wherein the C1-6 alkyl is optionally substituted with 1 to 5 substituents independently selected from CO2H, NRiRj, C6-10 aryl, C3-10 cycloalkyl, C5-10 heteroaryl and C5-10 heterocyclyl, wherein each Ri and Rj is independently H or C1-6 alkyl;
• wherein two of R1, R2 and R3 are H, and one of R1, R2 and R3 is other than H.