Small Molecule Inhibitors Selective For Polo-Like Kinase Proteins

A small molecule PLK inhibitor having the general structure:

• wherein
• R1 comprises an alkyl, —O-alkyl, —S-alkyl, or —NH-alkyl, and optionally includes a terminal aryl;
• R8 and R9 are independently hydrogen, alkyl, OH, NH2, SH, —S-alkyl, —O-alkyl, —NH-alkyl, —CONH-alkyl, halogen, or —CN;
• X is an amide, —C1 to C4 alkyl-NH—, —NH—, —SNH—, —SONH—, or —SO2N—;
• R7 is selected from the following structures:
• in which
• R2 through R6 are independently selected from hydrogen, carboxyl, alkyl, alkyl ester, hydroxyl, methoxy, halogen, sulfonamide, phosphate, nitro, methylamine, or boronic acid, and
• R10 is C or N, and R3 is relevant only when R10 is C;