Derivatives of macrocyclic n-aryl-tricyclopyrimidine-2-amine polyethers as inhibitors of ftl3 and jak

A compound of the following general formula (I):

• or a pharmaceutically acceptable salt and/or solvate thereof,
• wherein:
• W represents an oxygen or sulfur atom,
• X represents a saturated or unsaturated hydrocarbon chain comprising 1 to 3 carbon atoms, optionally substituted by one or more groups selected from a halogen atom, a (C1-C6)alkyl, oxo, OH and (C1-C6)alkoxy group, one or more carbon atoms of said chain being optionally each replaced, independently of each other, by an oxygen or sulfur atom,
• Y represents a nitrogen atom or a CRy group wherein Ry represents a hydrogen atom, a halogen atom, a (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy, (C1-C6)haloalkoxy, OH, CN, NO2, NR12R13, CO2H or CO2((C1-C6)alkyl) group,
• Q represents a single, double or triple bond, an oxygen or sulfur atom, or a (C1-C6)alkyl, S(O) or S(O)2 group,
• A1 and A2 represent, independently of each other, a single bond or a (C1-C6)alkyl group optionally substituted by an OH group, or A1 and A2 form with Q and the carbon atoms attached to Q an optionally substituted monocyclic carbocycle or heterocycle,
• R1, R2, R3, R4, R5, R6, R7, and R8 represent, independently of each other, a hydrogen atom or a (C1-C6)alkyl group,
• R9 and R10 represent, independently of each other, a hydrogen atom, a halogen atom, an optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, optionally substituted (C1-C6)alkoxy, optionally substituted (C1-C6)thioalkoxy, CN, NO2, NR14R15, OH, SH, CO2R54, CONR55R56 group, an optionally substituted carbocycle or an optionally substituted heterocycle,
• R11 represents a hydrogen atom, a halogen atom, or a (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy or (C1-C6)haloalkoxy group, and
• R12, R13, R14, R15, R54, R55 and R56 represent, independently of each other, a hydrogen atom or an optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, or optionally substituted (C2-C6)alkynyl group, or R12 and R13, and/or R14 and R15 and/or R55 and R56, independently of each other, form with the nitrogen atom that bears them an optionally substituted heterocycle.