Compounds for the inhibition of cyclophilins and uses thereof

A compound of formula I,

• or a pharmaceutically acceptable salt thereof, wherein:
• Ring A is C3-10 aryl, which is optionally substituted;
• each R′ is independently —R, halogen, -haloalkyl, -hydroxyalkyl, —OR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, or —N(R)2;
• each R1 is independently —H or C1-6 aliphatic which is optionally substituted;
• each R1a is independently —H or C1-6 aliphatic which is optionally substituted;
• or R1 and R1a taken together with the atom to which they are attached form a 3-7 membered carbocyclic ring optionally having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, which is optionally substituted;
• each R2 is independently —H or C1-6 aliphatic which is optionally substituted;
• each R2a is independently —H or C1-6 aliphatic which is optionally substituted;
• X is CH2 or O;
• or X and the bonds attached to X are absent;
• each R is independently hydrogen, C1-6 aliphatic, C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• each of which is optionally substituted;
• or
• two R groups on the same atom are taken together with the atom to which they are attached to form a C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
• each of which is optionally substituted;
• m is 1 or 2;
• n is 1 or 2;
• and
• p is 1, 2, 3, 4, or 5.