Cancer treatment utilizing sp-141 to bind with mdm2 and act as an inhibitor of mdm2 expression
AssigneeTexas Tech University System
InventorsRuiwen Zhang, Wei Wang
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Abstract
An SP-141 compound is a novel small molecule that can serve as a molecular-targeted chemotherapeutic agent. In one embodiment, the labeled compound can comprise SP-141, which comprises 6-methoxy-1-(naphthalen-1-yl)-9 H-pyrido[3,4-b]indote. The compound inhibits expression of oncogenes such as the Mouse Double Minute 2 protein. The compound can bind directly to Mouse Double Minute 2 to inhibit cancer growth including breast cancer growth.
Claims20
A labeled compound having the structure:
The labeled compound of claim wherein said compound binds directly to Mouse Double Minute 2 protein.
A labeled compound having the structure:
- wherein SP-141 comprises 6-methoxy-1-(naphthalen-1-yl)-9 H-pyrido[3,4-b]indole.
Dependencies are inferred from the claim text.