Optically Active a-Trifluoromethyl-B-Amino Acid Derivative Production Method

A method for producing an optically active α-trifluoromethyl-β-amino acid derivative, the method comprising:

• allowing a compound represented by the following General Formula (1) and a compound represented by the following General Formula (2) to react in the presence of a copper-optically active phosphine complex obtained from a copper compound and an optically active phosphine compound, to thereby obtain an optically active α-trifluoromethyl-β-amino acid derivative represented by the following General Formula (3):
• where in the General Formulas (1) to (3), R1 represents a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, or a substituted or unsubstituted alkynyl group, R2 represents a protective group of N, R3 and R4 each independently represent a substituted or unsubstituted aryl group, a substituted or unsubstituted heteroaryl group, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, or a substituted or unsubstituted alkynyl group, and R3 and R4 may form a ring structure with N.