Diamide macrocycles that are fxia inhibitors

A compound of Formula (I):

• or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof, wherein:
• is an optional bond;
• ring A is independently selected from a C3-10 carbocycle and a 5- to 10-membered heterocycle comprising:
• carbon atoms and 1-4 heteroatoms selected from N, NH, N(C1-4 alkyl), NC(═NH)NH2, O, and S;
• ring B is independently selected from a aryl and a 5- to 10-membered heterocycle;
• L1 is independently selected from a
• bond, —CR5R5—, —CHR5CHR5—, —CR5═CR5—, —C≡C—, —OCH2—, —CHR5NH—, —CH2O—, —SCH2—, —SO2CH2—, and —CH2NH—;
• R1 is, independently at each occurrence, selected from halogen, C1-6 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 haloalkyl, OH, ═O, OCH2F, OCHF2, OCF3, CF3, CN, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2, CO2(C1-4 alkyl), CO(C1-4 alkyl), —CH2NH2, —CONH2, —CONH(C1-4 alkyl), —OCH2CO2H, —NHCO(C1-4 alkyl), —NHCO2(C1-4 alkyl), —NHSO2(C1-4 alkyl), —SO2NH2, and —C(═NH)NH2;
• R2 is a 5- to 7-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NH, N(C1-4 alkyl), O, and S(O)2, wherein said heterocycle is substituted with 0-2 R2a;
• R2a is, independently at each occurrence, selected from halogen, C1-4 alkyl, —CH2OH, C1-4 alkoxy, OH, CF3, OCF3, OCH2F, OCHF2, CN, NH2, CO2H, CO2(C1-4 alkyl), COC1-4 alkyl, —CONH2, —CONH(C1-4 alkyl), —CON(C1-4 alkyl)2, —SO2(C1-4 alkyl), —SO2NH2, —SO2NH(C1-4 alkyl), and —SO2N(C1-4 alkyl)2;
• R3 is independently selected from H and C1-4 alkyl;
• alternatively, L1 and R3, together with the nitrogen atom to which they are attached, form a ring;
• R4 is selected from H, C1-4 alkyl, hydroxyl, F, CF3, and C3-6 cycloalkyl;
• R5 is selected from H and C1-4 alkyl;
• R6 is selected from H, halogen, C(O)OH, and C(O)O(C1-4 alkyl);
• R7 is selected from H, C1-4 alkyl, and CF3;
• alternatively, R6 and R7 together are ═O;
• and
• R8 is, independently at each occurrence, selected from H, halogen, NHCO2C1-4 alkyl, CN, OH, O—C1-4 alkyl, CF3, —OCF3, —OCHF2, —CHF2, —CH2F, CO2H, CO2(C1-4 alkyl), —CH2CO2H, —(CH2)2CO2H, —CH2CO2(C1-4 alkyl), —(CH2)2CO2(C1-4 alkyl), NH2, —CH2NH2, —NHCO(C1-4 alkyl), —NHCO2(CH2)1-2O(C1-4 alkyl), —NHCO2(CH2)1-3O(C1-4 alkyl), NHCO2CH2CH(C1-4 alkyl)O(C1-4 alkyl), —NHCO2(CH2)1-2OH, —NHCO2CH2CO2H, —CH2NHCO2(C1-4 alkyl), —NHC(O)NH(C1-4 alkyl), —NHC(O)N(C1-4 alkyl)2, NHC(O)NH(C1-4 alkyl)N(5- to 6-membered heterocycle), —NHSO2(C1-4 alkyl), —CONH2, —CONH(C1-4 alkyl), —CON(C1-4 alkyl)2, and —CH2CONH2.