2-aminopyrimidine compound and pharmaceutical composition and use thereof

A compound of formula I, or a pharmaceutically acceptable salt or stereoisomer thereof or a prodrug thereof:

• wherein R1 and R2 are each independently H, halogen, cyano, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C3-C6 cycloalkyl, substituted or unsubstituted C1-C6 alkoxy, and substituted or unsubstituted C3-C6 cycloalkoxy;
• R3 is H or —(CH2)mNR8R9;
• R4 and R5 are independently H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxy, halogen, —(CH2)mNR8R9, and —(CH2)mCR6R8R9;
• wherein each m is independently 0, 1, 2 or 3;
• R6 is H or C1-C3 alkyl;
• each R8 and each R9 are independently selected from H, substituted or unsubstituted C1-C6 alkyl, or R8, R9 and attached N or C together form an unsubstituted or substituted 3-8 membered monocyclic or fused ring containing 1, 2 or 3 heteroatoms selected from O, N, S;
• W is NH, N(C1-C3 alkyl), O or S;
• X, Y, Z are each independently N or —CR10, wherein R10 is H, halogen, substituted or unsubstituted C1-C3 alkyl, or substituted or unsubstituted C1-C3 alkoxy;
• is a substituted or unsubstituted 5 to 7 membered aromatic ring containing 0, 1, 2 or 3 heteroatoms selected from O, N or S;
• wherein each substituted independently means substituted by substituents selected from the group consisting of:
• halogen, hydroxy, amino, C1-C3 alkyl, C1-C3 alkoxy, —NH(C1-C3 alkyl), —N(C1-C3 alkyl)(C1-C3 alkyl), and —C(═O)(C1-C3 alkyl).