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US 2017/0283397 A1Published application
Substituted 1-h-indol-3-yl-benzamide and 1, 1'-biphenyl analogs as histone demethylase inhibitors
AssigneeUniversity of Utah Research Foundation
InventorsHariprasad Vankayalapati, Sunil Sharma, Xiaohui Liu, Srinivas Kasibhatla
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Abstract
Substituted 1-H-indol-3-yl-benzamide and 1, 1′-biphenyl analogs derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1.
Claims6
A compound having a structure of Formula I or II.
- wherein:
- n is selected from the group consisting of 0, 1 and 2;
- X1 and X2 are independently selected from —CH and —N;
- Z is selected from the group consisting of —O, —S, —NH, and —SO2;
- R1 is selected from the group consisting of
- R2 is selected from the group consisting of —H, —CH3, —HO, —NH2, halo, —CF3, OCF3, —OCH3, and CN, and wherein R2 can also be optionally substituted;
- R3 is selected from the group consisting of C1-6 alkyl, C1-6 cycloalkyl, halo-C1-6 alkyl, cycloalkyl, and C1-6 heterocycloalkyl;
- R4, R5 and R6 are each independently selected from the group consisting of —H, —CH3, —HO, —NH2, halo, —CF3, OCF3, —OCH3, and CN;
- and
- R7 and R8 are each independently selected from the group consisting of —H and —CH3;
- or an isomer or a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.