Bruton's Tyrosine Kinase Inhibitors

A compound having Formula (I)

• or a pharmaceutically acceptable salt thereof, wherein
• A is arylene, 5-membered heteroarylene or 6-membered heteroarylene, optionally substituted with one, two, three or four R6 independently selected from the group consisting of (C1-C4)alkyl, halo(C1-C4)alkyl, halo, hydroxy and (C1-C4)alkoxy;
• X is O, S, C(═O), C(OR4) or C(R5a)(R5b);
• W is aryl, 5-membered heteroaryl or 6-membered heteroaryl, optionally substituted with one, two, three, four or five R7 independently selected from the group consisting of (C1-C4)alkyl, halo(C1-C4)alkyl, (C3-C6)cycloalkyl, 4-6 membered saturated heterocycle, halo, hydroxy, hydroxy(C1-C4)alkyl, (C1-C4)alkoxy, hydroxy(C2-C4)alkoxy, and halo(C1-C4)alkoxy;
• R1 is a 4-8 membered nitrogen-containing heterocyclyl substituted on said nitrogen with R and optionally further substituted with one, two, three, four or five substituents independently selected from the group consisting of (C1-C4)alkyl, halo(C1-C4)alkyl, halo, hydroxyl and (C1-C4)alkoxy;
• R is cyano, cyano(C1-C3)alkyl, R or;
• R2a, R2b, R3a, R3b and R4 are independently selected from the group consisting of hydrogen or (C1-C3)alkyl;
• R5a and R5b are independently selected from the group consisting of hydrogen, halo and (C1-C3)alkyl;
• Ra is hydrogen, halo, cyano, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C1-C4)alkylthio, (C1-C4)alkylsulfonyl, or (C1-C6)alkyl optionally substituted by halo, hydroxyl, (C1-C6)alkoxy or halo(C1-C6)alkoxy;
• Rb and Rc are independently selected from the group consisting of hydrogen, halo, cyano, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C3-C6)cycloalkyl, C(═O)Rd and (C1-C6)alkyl optionally substituted with one, two or three Rf independently selected from the group consisting of halo, hydroxyl, N(Re)2, (C1-C6)alkoxy, halo(C1-C6)alkoxy and aryl;
• or Rb and Rc taken together with the carbon to which they are bound form a 4-7 membered carbocycyl or heterocycyl optionally substituted with one, two or three Rf independently selected from the group consisting of halo, hydroxyl, N(Re)2, (C1-C6)alkoxy;
• halo(C1-C6)alkoxy and aryl;
• Rd is (C1-C6)alkyl, (C1-C6)alkoxy, N(Re)2 or aryl;
• Re is independently selected for each occurence from the group consisting of hydrogen and (C1-C4) alkyl, or both Re taken together with the nitrogen atom to which they are bound form a 4-7 membered heterocycyl;
• and
• G is a 5-7 membered carbocycyl or heterocycyl optionally substituted with one, two or three Rf independently selected from the group consisting of halo, hydroxyl, N(Re)2, (C1-C6)alkoxy;
• halo(C1-C6)alkoxy and aryl.