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US 2017/0283384 A1Published application
Psma targeted fluorescent agents for image guided surgery
AssigneesThe Johns Hopkins University, Intuitive Surgical Operations, Inc.
InventorsMARTIN G. POMPER, RONNIE C. MEASE, YING CHEN, SANGEETA RAY, JONATHAN SORGER
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Abstract
Compositions and methods for visualizing tissue under illumination with near-infrared radiation, including compounds comprising near-infrared, closed chain, sulfo-cyanine dyes and prostate specific membrane antigen ligands are disclosed.
Claims34
A compound of the following formula:
- or a pharmaceutically acceptable salt thereof.
A composition comprising compound (3):
- or a pharmaceutically acceptable salt thereof;
- wherein the composition is adapted for visualization of tissue under illumination with near-infrared radiation.
A method for visualization of tissue expressing PSMA, the method comprising administering to a subject a composition comprising compound (3):
- or a pharmaceutically acceptable salt thereof;
- wherein compound (3) is administered in an amount sufficient for imaging tissue under illumination with near-infrared radiation;
- imaging the tissue under illumination with near-infrared radiation;
- and
- obtaining at least one image of tissue from the subject.
2 more elements
Dependencies are inferred from the claim text.