Androgen receptor modulators and methods for their use

A compound having the following structure (I):

• or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein:
• Y1 and Y2 are each independently O or S;
• R1 is H, C1-C6 alkyl or C1-C6 haloalkyl;
• R2 is H, —C(═O)R7 or —S(O)nR8;
• at least one of R3 or R4 is a straight-chain C1-C6 haloalkyl, and the other one of R3 or R4 is C1-C6 alkyl or C1-C6 haloalkyl;
• R5 and R6 are each independently H, OH, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl or C1-C6 haloalkoxy;
• R7 is C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl or C1-C6 haloalkoxy;
• R8 is C1-C6 alkyl or C1-C6 haloalkyl;
• is a carbon-carbon double bond or a carbon-carbon single bond, such that all valences are satisfied;
• and
• n is 0, 1 or 2.