US 2017/0281914 A1 · LOCALIZED TREATMENT OF TISSUES THROUGH TRANSCATHETER DELIVERY OF ACTIVE AGENTS

Abstract

Embodiments herein include catheters and methods for the localized treatment of tissues through transcatheter delivery of active agents. In an embodiment, a method herein can include inserting a catheter into the lumen of a blood vessel. The catheter can include an inflatable balloon, a first lumen within the shaft for delivering a fluid to inflate the balloon, an active agent delivery port, and a second lumen disposed within the shaft for delivering the active agent composition through the shaft to the active agent delivery port. The method can include inflating the balloon to at least partially occlude the flow of blood through the blood vessel. The method can include ejecting the active agent composition from the active agent delivery port into the blood vessel. In an embodiment, a catheter for treating a localized region of the body with an active agent composition is included. Other embodiments are also included herein.

Claims20

Dependent claims

A method of treating a localized region of the body with an active agent composition comprising:

inserting a catheter into the lumen of a blood vessel of a patient, the catheter comprising a shaft including a proximal end and a distal end, the catheter further comprising an inflatable balloon, a first lumen disposed within the shaft for delivering a fluid to inflate the balloon, an active agent delivery port, and a second lumen disposed within the shaft for delivering the active agent composition through the shaft to the active agent delivery port;
inflating the balloon to at least partially occlude the flow of blood through the blood vessel of the patient;
ejecting the active agent composition out of the active agent delivery port into the blood vessel, the active agent composition comprising:
a cationic delivery agent;
a therapeutically effective amount of the hydrophobic active agent;
and
a pharmaceutically acceptable carrier;
deflating the balloon to restore the flow of blood through the blood vessel;
and
withdrawing the catheter from the lumen of the blood vessel of the patient.

7 more elements

Dependencies are inferred from the claim text.

Localized treatment of tissues through transcatheter delivery of active agents

Life of this patent

Localized treatment of tissues through transcatheter delivery of active agents

Life of this patent

Abstract

Claims20