Igf-i for myocardial repair
AssigneeUniversity College Cork, National University of Ireland, Cork
InventorNoel Caplice
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Abstract
Provided herein are methods for treating an individual having (suffering from) an acute myocardial infarction and drug eluting stents useful for treating such individuals. These methods include treating an individual by introducing, such as by surgically inserting, at a site of an acute coronary artery occlusion upstream of the site of acute myocardial infarction, a drug eluting stent (DES) that is capable of eluting from 25 pg to 950 pg of IGF-I directly into the coronary circulation. The treatment is specifically directed to stimulation of repair or survival of damaged cardiac muscle or left ventricular remodeling.
Claims8
-44. (canceled)
A method of treating a mammal that has suffered a myocardial infarction to stimulate repair or survival of cardiac muscle damaged by the infarct, or to stimulate left ventricular remodeling, the method comprising a step of administering IGF-1 to the mammal by intracoronary infusion upstream of the myocardial infarction in sufficient quantity to reduce the effects of the myocardial infarction on the mammal by exerting anti-apoptotic and/or cardiotrophic effects on the affected or diseased tissue
Dependencies are inferred from the claim text.