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US 2017/0281799 A1Published application
Systems and methods for screening ototoxic, otoprotective, and otoregenerative compounds using aquatic models
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsMarvin SLEPIAN, Abraham JACOB, Maki NIIHORI
Life of this patent
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Abstract
The present disclosure relates to devices, systems, and methods for screening compounds and materials for otoxicity and otoprotective activity. In particular, the present invention relates to a model organism (e.g., Danio rerio) and system for measuring behavior associated with hair cell loss.
Claims24
1-10. (canceled)
A method of screening compounds for otoprotective or regenerative activity, comprising:
- a) contacting a fish that exhibits altered behavior in response to loss of hair cell mass with a ototoxic agent and a test compounds;
- and
- b) identifying test compounds that alter, treat, or prevent ototoxicity caused by said ototoxic agent or have regenerative activity by measuring changes in said behavior.
(canceled)
A system, comprising:
- a) a multichamber device comprising a plurality of wells, each well comprising one or more fish or organisms that exhibit altered behavior in response to exogenous agent exposure;
- b) one or more fluid exchange components;
- c) a detection of behavior component;
- and
- d) a data analysis component.
2 more elements
29-31. (canceled)
A method of treating or preventing hearing loss, comprising:
- administering sulforaphane to a subject at risk of hearing loss or demonstrating symptoms of hearing loss.
35-37. (canceled)
Dependencies are inferred from the claim text.