Anti-mesothelin antibodies and immunoconjugates
AssigneeGenentech, Inc.
InventorsMark DENNIS, Suzanna J. SCALES, Susan D. SPENCER, Yin ZHANG
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Abstract
The invention provides anti-mesothelin antibodies and immunoconjugates and methods of using the same.
Claims27
An isolated antibody that binds to mesothelin, wherein the antibody comprises (i) HVR-H1 comprising the amino acid sequence of SEQ ID NO:36, (ii) HVR-H2 comprising the amino acid sequence of SEQ ID NO:37, (iii) HVR-H3 comprising the amino acid sequence of SEQ ID NO:39, (iv) HVR-L1 comprising the amino acid sequence of SEQ ID NO:33, (v) HVR-L2 comprising the amino acid sequence of SEQ ID NO:34, and (vi) HVR-L3 comprising the amino acid sequence of SEQ ID NO:35.
-62. (canceled)
An antibody comprising a VH sequence of SEQ ID NO:
- 16 and a VL sequence of SEQ ID NO:
- 12.
The antibody of claim 81, wherein the label is a positron emitter.
The antibody of claim 82, wherein the positron emitter is 89Zr.
Dependencies are inferred from the claim text.