US 2017/0281790 A1 · ENGINEERED FGF COMPOSITIONS AND METHODS OF USE THEREOF

Abstract

The present invention relates to the development of stable mutants of FGF-1 and FGF-2. In particular, it relates to novel engineered FGF-1 and FGF-2 polypeptides as well as polynucleotides, DNA constructs, and vectors encoding such polypeptides. In another aspect, pharmaceutical compositions and hydrogels including the disclosed polypeptides, polynucleotides, DNA constructs, and vectors are provided. In a still further aspect, methods of treating conditions using the compositions disclosed herein are provided.

Claims21

Dependent claims

A FGF polypeptide comprising a polypeptide selected from the group consisting of SEQ ID NO:

4, SEQ ID NO:
6, SEQ ID NO:
10, SEQ ID NO:
12, a polypeptide having 80% sequence identity to at least one of SEQ ID NOs:
4, 6, 10 or 12 and comprising amino acid residue of 122 of SEQ ID NO:
4 or SEQ ID NO:
6 or amino acid residue 138 of SEQ ID NO:
10 or SEQ ID NO:
12, fragments comprising amino acid residue 122 of SEQ ID NO:
4 or SEQ ID NO:
6, fragments comprising amino acid residue 138 of SEQ ID NO:
10 or SEQ ID NO:
12, a fragment of SEQ ID NOs:
4 or 6 comprising amino acids 112-128 and a fragment of SEQ ID NOs:
10 or 12 comprising amino acids 128-144.

12 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/474,268Filed 30 Mar 2017

Priority

30 Mar 2016

Published

5 Oct 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

C07K 14/71
Receptors; Cell surface antigens; Cell surface determinants: for growth factors; for growth regulators
A61K 38/16
Medicinal preparations containing peptides: peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A61K 47/68
The non-active ingredient being a modifying agent: the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
C07K 14/50
Growth factors; Growth regulators: fibroblast growth factor [FGF]

Engineered fgf compositions and methods of use thereof

Life of this patent

Engineered fgf compositions and methods of use thereof

Life of this patent

Abstract

Claims21