Back to results
US 2017/0281785 A1Published application
Glycerol linked pegylated sugars and glycopeptides
AssigneeNovo Nordisk A/S
InventorsShawn DeFrees, Xiao Nong Zeng
Life of this patent
Estimating the term…
Abstract
The present invention provides conjugates between peptides and PEG moieties through glycerol linkers.
Claims4
A peptide conjugate comprising:
- a) a peptide which is covalently attached to a moiety which is a member selected from:
- in which R2 is a member selected from H, CH2OR7, COOR7 and OR7,
- wherein R7 is a member selected from H, substituted or unsubstituted alkyl and substituted or unsubstituted heteroalkyl;
- R3, R4, R5 and R6 are members independently selected from H, substituted or unsubstituted alkyl, OR8 and NHC(O)R9;
- wherein R8 and R9 are independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, sialic acid and polysialic acid;
- and wherein at least one of R3, R4, R5, R6 includes a moiety which is a member selected from:
- in which the indices m and n are integers independently selected from 1 to 1000;
- A1, A2, A3, A4, A5, A6, A7, A8, A9, A10 and A11 are members independently selected from H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —NA12A13, —OA12 and -SiA12A13;
- wherein
- A12 and A13 are members independently selected from substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl.
7 more elements
Dependencies are inferred from the claim text.