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US 2017/0281780 A1Published application
Colloidal dispersion comprising hpmcas
AssigneeCapsugel Belgium NV
InventorsJonathan Leonard Cape, Warren Kenyon Miller, Dwayne Thomas Friesen, Hassan Benameur, Maryline Clauzel, David Thomas Vodak
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Abstract
The present disclosure relates to compositions of an aqueous colloidal dispersion of hydroxypropyl methyl cellulose acetate succinate (HPMCAS), and methods for making such colloidal dispersions.
Claims20
A composition comprising:
- an aqueous colloidal dispersion comprising
- hydroxypropyl methyl cellulose acetate succinate (HPMCAS),
- a dispersant,
- a plasticizer, and
- a non-polymeric, ionizable surface modifier, wherein said non-polymeric, ionizable surface modifier is an aliphatic carboxylic acid, a dicarboxylic acid, a hydroxy carboxylic acid, or a benzoic acid,
- wherein the composition has a pH of from about 3.6 to about 5.3.
3 more elements
A process for making a composition comprising:
- a. dissolving hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and a plasticizer in an organic solvent to form an organic phase;
- b. combining water, a dispersant, and a base to form an aqueous phase;
- c. combining the organic phase and the aqueous phase to form a mixture;
- d. homogenizing said mixture to form an emulsion;
- e. removing substantially all said organic solvent from said mixture;
- f. adding a non-polymeric, ionizable surface modifier to said aqueous dispersion, wherein the non-polymeric, ionizable surface modifier is an organic acid or a compound of a multivalent cation;
- and
- g. adjusting the water concentration of said mixture by removing water to obtain an aqueous dispersion of HPMCAS.
5 more elements
A process for making a composition comprising:
- a. dissolving hydroxypropyl methyl cellulose acetate succinate (HPMCAS) and a plasticizer in an organic solvent to form an organic phase;
- b. adding a non-polymeric, ionizable surface modifier to said organic phase, wherein the non-polymeric, ionizable surface modifier is an organic acid or a compound of a multivalent cation;
- c. combining water, a dispersant, and a base to form an aqueous phase;
- d. combining the organic phase and the aqueous phase to form a mixture;
- e. homogenizing said mixture to form an emulsion;
- f. removing substantially all said organic solvent from said mixture;
- and
- g. adjusting the water concentration of said mixture by removing water to obtain an aqueous dispersion of HPMCAS.
5 more elements
Dependencies are inferred from the claim text.