Steroid hormone compositions in medium chain oils
AssigneeTherapeuticsMD, Inc.
InventorsAnnette SHADIACK, Peter H.R. PERSICANER, Philip B. INSKEEP, Thorsteinn THORSTEINSSON, Frederick D. SANCILIO, Jason D. LEGASSIE
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Abstract
This disclosure provides a novel pharmaceutical composition capable of forming micelles upon exposure to the gastric environment. The pharmaceutical composition is suitable for delivering steroid hormones, and progesterone in particular, to a subject in need thereof
Claims21
A pharmaceutical composition for providing enhanced oral bioavailability of progesterone, the pharmaceutical composition comprising:
- progesterone, a polysorbate, and a medium chain oil, wherein
- the medium chain oil comprises at least about 50 weight percent of a
- predominantly medium chain monoglyceride;
- and
- the progesterone is fully solubilized.
An oral, fully-solubilized progesterone pharmaceutical composition comprising:
- progesterone and a polysorbate in a weight ratio of from about 1:2 to about 2:1;
- and
- a medium chain oil comprising a mixture of medium chain mono- and diglycerides, the medium chain oil not containing more than about 10 weight percent triglycerides.
A pharmaceutical composition for providing enhanced oral bioavailability of progesterone, the pharmaceutical composition comprising:
- progesterone, a polysorbate, and a medium chain oil, wherein
- the medium chain oil comprises at least about 50 weight percent of a first medium chain oil component;
- and
- the progesterone is fully solubilized.
Dependencies are inferred from the claim text.