Method of treating alvelor bone loss through the use of anti-sclerostin antibodies
AssigneesAmgen Inc., The Regents of the University of Michigan
InventorsHua Zhu Ke, Min Liu, William V. Giannobile
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Abstract
The invention provides a method of treating alveolar bone loss involving administration of a sclerostin inhibitor to a subject in need thereof.
Claims18
A method for increasing alveolar bone height in a subject suffering from alveolar bone loss comprising administering to the subject an anti-sclerostin antibody in an amount effective to decrease the distance between the cement-enamel junction and the alveolar bone crest, at a dose from about 5 mg to about 1,000 mg per week, and wherein the anti-sclerostin antibody comprises a light chain variable region amino acid sequence set forth in SEQ ID NO:
- 376 and a heavy chain variable region amino acid sequence set forth in SEQ ID NO:
- 378.
18-32. (canceled)
Dependencies are inferred from the claim text.