Compositions comprising ch505 envelopes, and trimers
AssigneesDuke University, Los Alamos National Security, LLC
InventorsBarton F. HAYNES, Hua-Xin LIAO, Bette T. KORBER, Peter T. HRABER
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Abstract
In certain aspects the invention provides a selection of HIV-1 envelopes suitable for use as immunogens, and methods of using these immunogens to induce neutralizing antibodies. In certain embodiments, the immunogens are designed to trimerize. In other embodiments, the immunogens comprise an immune modulating component.
Claims18
A composition comprising any one of the HIV-1 envelope polypeptides corresponding to the HIV-1 envelopes CH505.M6, CH505.M11, CH505w020.14, CH505w030.28, CH505w078.15, CH505w053.31, CH505w030.21, CH505w078.33, CH505w053.16, CH505w100.B6 or a combination thereof, or polynucleotide encoding the same.
A composition comprising any one of the HIV-1 envelope polypeptides corresponding to the HIV-1 envelopes CH505.T/F;
- CH505.M11;
- CH505w020.14;
- CH505w030.28;
- CH505w030.21;
- CH505w053.16;
- CH505w053.31;
- CH505w078.33;
- CH505w078.15;
- CH505w100.B6 or a combination thereof, or a polynucleotide encoding the same.
A composition comprising any one of the HIV-1 envelope polypeptides corresponding to the HIV-1 envelopes CH505.M11, CH505.w004.03, CH505.w020.14, CH505.w030.28, CH505.w030.12, CH505.w020.2, CH505.w030.10, CH505.w078.15, CH505.w030.19 CH505.w030.21 or a combination thereof, or polynucleotide encoding the same.
A composition comprising MPER-peptide-liposome-CD40L conjugate.
Dependencies are inferred from the claim text.