Interaction of moraxella catarrhalis with epithellal cells, extracellular matrix proteins and the complement system
AssigneeArne Forsgren AB
InventorsArne FORSGREN, Kristian RIESBECK
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Abstract
The present disclosure relates to surface proteins of Moraxella catarrhalis and their ability to interact with epithelial cells via cell-associated fibronectin and laminin, and also to their ability to inhibit the complement system. These surface proteins are useful in the preparation of vaccines. The present disclosure also provides peptides interacting with fibronectin, laminin and the complement system.
Claims8
1-27. (canceled)
An isolated polypeptide consisting of a sequence that is at least 95% identical to SEQ ID NO:6, or a hydroxylation product, sulphonation product, or glycosylation product of said polypeptide, wherein the polypeptide or product retains fibronectin-binding activity.
An isolated ligand consisting of a sequence that is at least 95% identical to SEQ ID NO:6, or of a hydroxylation product, sulphonation product, or glycosylation product of said ligand, wherein said ligand retains fibronectin binding activity.
Dependencies are inferred from the claim text.