Back to results
US 2017/0281742 A1Published application
H3.3 CTL Peptides and Uses Thereof
AssigneeThe Regents of the University of California
InventorsHideho OKADA, Yafei HOU
Life of this patent
Estimating the term…
Abstract
Peptides that generate an immune response to glioma-related H3.3 proteins and methods of their use are provided.
Claims17
A composition for stimulating an immune response to replication-independent histone 3 variant H3.3 or H3.1, the composition comprising:
- a peptide consisting of less than 100 amino acids, wherein the peptide comprises (R/A)MSAP(S/A)TGGV (SEQ ID NO:1);
- and
- an adjuvant.
6-28. (canceled)
34-36. (canceled)
A T-cell expressing a polypeptide comprising a T-cell receptor (TCR), or a peptide/MHC complex binding fragment thereof, that binds a peptide consisting of 10-12 amino acids, wherein the peptide comprises (R/A)MSAP(S/A)TGGV (SEQ ID NO:1) in a peptide/MHC complex.
41-57. (canceled)
Dependencies are inferred from the claim text.