Serodiagnosis of salmon poisoning disease
AssigneeOhio State Innovation Foundation
InventorsYasuko Rikihisa, Mingqun Lin
Life of this patent
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Abstract
Neorickettsia helminthoeca is an obligate intra-cytoplasmic bacterium that causes salmon poisoning disease (SPD), an acute, febrile, fatal disease of dogs. Disclosed are compositions and methods for the immunodetection of N. helminthoeca in a canine subject. Also disclosed are immunogenic N. helminthoeca peptides that can be used in a vaccine for N. helminthoeca.
Claims20
An immunogenic composition comprising one or more isolated Neorickettsia helminthoeca proteins, or immunogenic fragments or variants thereof, or a fusion protein containing same, and a pharmaceutically acceptable carrier,
- wherein said composition is capable of producing antibodies specific to N. helminthoeca in a subject to whom the immunogenic composition has been administered, and
- wherein the isolated N. helminthoeca protein is selected from the group consisting of:
- SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, and SEQ ID NO:5.
A method of preventing or inhibiting salmon poisoning disease (SPD) in a subject comprising:
- administering to the subject an immunogenic composition comprising one or more isolated Neorickettsia helminthoeca proteins, or immunogenic fragments or variants thereof, or a fusion protein containing same, and a pharmaceutically acceptable carrier,
- wherein said composition is administered in an amount effective to prevent or inhibit salmon poisoning disease (SPD), and
- wherein the isolated N. helminthoeca protein is selected from the group consisting of:
- SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, and SEQ ID NO:5.
A method for detecting Neorickettsia helminthoeca infection in a canine subject, comprising assaying a sample from the subject for antibodies specific for a N. helminthoeca protein selected from the group consisting of P51, NSP1, NSP2, NSP3, and SSA.
Dependencies are inferred from the claim text.