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US 2017/0281738 A1Published application
Compositions and methods relating to argininosuccinate synthetase
AssigneeBanyan Biomarkers, Inc.
InventorsStanislav I. Svetlov, Victor Prima, Alvin Wang, Gabriel Molina, Kevin Ka-wang Wang
Life of this patent
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Abstract
Processes and compositions for the therapeutic treatment of pathogenic Gram-negative bacterial infection are provided whereby argininosuccinate synthetase or PEGylated argininosuccinate synthetase is administered to a subject to inactivate endotoxin thereby reducing the likelihood of bacterial sepsis and improving patient outcome.
Claims6
A process of detecting exposure to bacterial endotoxin by a subject, comprising:
- obtaining a sample from said subject exposed to a bacterial endotoxin absorbed from an infected wound and circulating in blood of said subject prior to said obtaining;
- determining that levels and activity of argininosuccinate synthetase in said sample from said subject are elevated over a normal level and normal activity of arginosuccinate synthetase absent exposure to bacterial endotoxin.
Dependencies are inferred from the claim text.