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US 2017/0281730 A1Published application
Compositions and Methods for the Systemic Treatment of Arthritis
AssigneeBaylor Research Institute
InventorsJacques F. Banchereau, Maria Virginia Pascual
Life of this patent
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Abstract
The present invention includes compositions and methods for treating arthritic joints found in patients with autoinflammation, e.g., systemic onset juvenile idiopathic arthritis, by administering at the site of inflammation a therapeutically effective amount of at least one agent that reduces or blocks the bioavailability of interleukin-1β.
Claims6
-24. (canceled)
A method for evaluating cells from a patient comprising incubating a patient's sera with non-autologous healthy blood mononuclear cells (PBMCs) in vitro;
- measuring IL-1β expression in the PBMCs;
- and, comparing the measured level to the level of expression of IL-1β in a non-SOJIA patient
Dependencies are inferred from the claim text.