Use of inhibitors of binding between a par-1 receptor and its ligands for the treatment of glioma
AssigneeUniversity of Rochester
InventorsSteven A. Goldman, Romane Auvergne
Life of this patent
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Abstract
The present invention relates to a method of treating glioma in a subject. The method comprises selecting a subject having a glioma, providing an inhibitor of binding between a PAR-1 receptor and a ligand of the PAR-1 receptor, and administering the inhibitor to the selected subject under conditions effective to treat the glioma and/or prevent spread of tumor cells. Methods for inhibiting proliferation of glioma cells and/or precursors thereof and a method of screening for compounds suitable for treating glioma in subjects are also disclosed.
Claims23
A method of treating glioma in a subject comprising:
- selecting a subject having a glioma;
- providing a small molecule PAR1 antagonist;
- and
- administering the small molecule PAR1 antagonist to the selected subject under conditions effective to treat the glioma and/or prevent spread of tumor cells.
2-5. (canceled)
16-18. (canceled)
A method of inhibiting proliferation of glioma cells and/or precursors thereof, said method comprising:
- providing a small molecule PAR1 antagonist and
- contacting the small molecule PAR1 antagonist with glioma cells and/or precursors thereof under conditions effective to inhibit proliferation of the glioma cells and/or precursors thereof.
27-33. (canceled)
A method of screening for compounds suitable for treating glioma in subjects, said method comprising:
- providing a collection of candidate compounds;
- providing a PAR-1 receptor;
- providing a ligand of the PAR-1 receptor;
- contacting the collection, the PAR-1 receptor, and the ligand under conditions effective for the ligand to bind to the PAR-1 receptor in the absence of the collection;
- and
- identifying, as potential glioma therapeutics, those candidate compounds which are small molecule PAR1 antagonists.
Dependencies are inferred from the claim text.