Peptide conjugates of glp-1 receptor agonists and gastrin and their use

A peptide conjugate or pharmaceutically acceptable salt thereof having the formula I

• R1—Z-L-Y—R2 (I)
• wherein
• R1 is H, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl;
• R2 is OH or NH2;
• Z comprises the sequence of Exendin-4(1-39) having the sequence
• His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-
• Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-
• Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-
• Pro-Pro-Ser
• or an analogue thereof Za, wherein Za has substitutions in up to 10 positions, and/or comprises a C-terminal truncation of 1 to 12 amino acids, with respect to the sequence of Exendin-4;
• L is an optional linker moiety;
• and
• Y comprises the sequence of Gastrin17 having the sequence
• Gln-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Y15-Asp-Phe
• wherein Y15 is selected from Leu, Nle, Phe and Thr
• or an analogue thereof Ya, wherein Ya has substitutions in up to 5 positions with respect to the sequence of Gastrin17.