Phage therapy for targeting enterococci
AssigneesYissum Research Development Company of the Hebrew University of Jerusalem, Hadasit Medical Research Services and Development Ltd.
InventorsNissan Ronen HAZAN, Nurit BEYTH
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Abstract
Isolated bacteriophages having genomes comprising the nucleic acid sequences as set forth in SEQ ID NOs: 1 and 2, or variants thereof, and compositions comprising the bacteriophages in a ratio ranging from 1:10 to 10:1, respectively. Further provided are uses of the compositions in treating or preventing an infection inflicted by a bacteria (e.g., Enterococcous faecalis and/or Enterococcous faecium). As a non-limiting example, the composition may be used in treating or preventing a root canal infection.
Claims19
A composition comprising:
- i. an isolated strain of bacteriophage having a genome comprising a nucleic acid sequence of SEQ ID NO:
- 1, or a sequence having at least 95% sequence identity thereto;
- and
- ii. an isolated strain of bacteriophage having a genome comprising a nucleic acid sequence of SEQ ID NO:
- 2, or a sequence having at least 95% sequence identity thereto,
- wherein a ratio between the isolated strains of bacteriophage having a genome comprising the nucleic acid sequence of SEQ ID NOs:
- 1 and 2 ranges from 10:1 to 1:10, respectively.
A composition comprising one or more isolated strains of bacteriophages selected from the group consisting of:
- i. an isolated strain of bacteriophage having a genome comprising a nucleic acid sequence of SEQ ID NO:
- 1, or a sequence having at least 95% sequence identity thereto;
- and
- ii. an isolated strain of bacteriophage having a genome comprising a nucleic acid sequence of SEQ ID NO:
- 2, or a sequence having at least 95% sequence identity thereto.
A method for treating a subject inflicted or at risk of being inflicted with a bacterial infection, the method comprising administering to said subject an effective amount of an agent selected from the group consisting of:
- a. an isolated strain of bacteriophage having a genome comprising a nucleic acid sequence of SEQ ID NO:
- 1, or a sequence having at least 95% sequence identity thereto;
- and
- b. an isolated strain of bacteriophage having a genome comprising a nucleic acid sequence of SEQ ID NO:
- 2, or a sequence having at least 95% sequence identity thereto;
- c. a combination of (a) and (b).
Dependencies are inferred from the claim text.